TechRadar.com put together a list of the "10 easiest ways to boost your online security", a list that mostly focuses on minimizing your risk of infection online. With the rise, and continued threat, of Conficker, a list like this will help you augment your security defenses.
Some of this is a little technical, so read on here for full details.
The list is, however, missing one major thing, so I'm going to put that at item zero - UPDATE your software. This includes your operating system as well as the software that runs on it - most of this you can automate, but don't keep dismissing those reminders to update and restart. At least 11% of PCs are currently unpatched with the latest Microsoft update, making them even more vulnerable to threats such as Conficker.